Preconception Formula

Description

Prolog Preconception Formula is a nutritional supplement that may enhance female fertility. This product has been developed to meet the nutritional requirements associated with successful conception and reproductive health and these levels of specific, fertility-promoting supplements would be difficult to achieve through diet alone.

This product is designed for the female who may have impaired egg quality. It is also for the couple where at least one partner is greater than 35 years of age, as well as those having difficulty conceiving, undergoing fertility treatments by inseminations or IVF, or with unexplained infertility.

Partial Ingredient List:

Vitamins C: Help protect oocytes and other cells from oxidative stress and cellular damage.
Vitamin D3: Studies suggest roles for Vitamin D in bone and joint and cardiovascular health. It may also help guard against certain cancers. In reproductive medicine, observational studies have suggested that Vitamin D is involved in successful implantation of the embryo and early pregnancy maintenance.
L-Methyl Folate: As a coenzyme, folate is essential for DNA synthesis and cell division as well as amino acid metabolism and cell maturation. Folate is crucial for normal embryonic development. When taken prior to and during the first thirty days of pregnancy, adequate amounts of folic acid may reduce the incidence of neural tube defects such as spina bifida, myelomeningocele and anencephaly. Folate may also help prevent premature deliveries, low birth weight babies, and congenital defects cleft lip and palate.
Coenzyme Q10 (CoQ 10): Ubiquinone, is mainly known for its role as a proton and electron carrier in mitochondria (the cell’s “power plant”) and is also an antioxidant, ubiquitous in cell membranes.
French Maritime Pine Bark Extract: A source of several potent antioxidants including proanthocyanidins, Pine Bark Extract protects the egg cells from oxidative damage. It is also thought to improve circulation and combat the inflammation associated with endometriosis.
Grape seed extract and Lycopene: Potent antioxidants that promote normal cell development and guard against oxygen radicals.

Additional information

Weight	1 lbs

PRECONCEPTION

Supplement Facts
Serving Size: 3 Capsules Servings per Container: 30
	Amount Per Serving	DV%
Vitamin C (as ascorbic acid)	500 mg	833%
Vitamin D3 (4,000 IU) (as cholecalciferol)	100 mcg	450%
L-Methyl Folate 1,333 mcg DFE (Folic Acid 800 mcg)	1,333 mcg DFE	200%
CoQ10 (Ubiquinone)	600 mg	†
French Maritime Pine Bark Extract 95%	100 mg	†
Grapeseed Extract 95%	100 mg	†
Lycopene 10%	15 mg	†
* Percent Daily Values are based on a 2,000 calorie diet. † Daily Value not established. Other Ingredients: Hypromellose capsule, Microcrystalline Cellulose and Vegetable Magnesium Stearate

The Scientific Basis:

The Scientific Basis: Generally, 40% of the couples with impaired fertility have a female factor as primary cause. There is increasing evidence that preconceptional nutritional status plays an important role in fertility and long-term health of the offspring and dietary interventions and nutritional supplements may counteract the deleterious effects of oxidative stress on female fertility and oocyte (egg) health. During normal metabolism, reactive oxygen species (ROS) are generated on an ongoing basis, either by external or internal causes and ROS are critical for many processes in the human body, including certain intracellular signaling pathways. However, when there is an imbalance between oxidants and buffering antioxidants there is oxidative stress. Oxidative stress can negatively impact fertility by directly and indirectly affecting multiple processes in the female reproductive system. ROS, or oxygen radicals, such as hydrogen peroxides, superoxide anions, singlet oxygen and hydroxyl radicals, are the natural byproducts of oxygen metabolism. Oxygen radicals, however, are unstable, toxic molecules that contain one unpaired electron. These unpaired electrons make free radicals highly reactive such that they can react with lipids, amino acids and DNA/RNA in their vicinity. One free radical can spark a chain reaction, instantly causing a cascade of new free radicals. In the normal state, the follicular fluid contains antioxidants which both negate the effects of these ROS and which protect the egg cells from oxidative damage. However, during times of physical or environmental stress, the concentration of ROS can increase markedly, leading to extensive egg DNA damage. It has been suggested that in addition to damaging oocytes within developing follicles, oxidative stress may affect oocyte maturation, fertilization and embryo development and may be involved in the planned cell damage and death (apoptosis) of oocytes associated with the age-related decline in female fertility. Coenzyme Q10, ubiquinone, present in circulating lipoproteins is a potent antioxidant. At the cellular level it can increase energy production and affect gene expression. Observational studies have suggested that supplementation may improve pregnancy rates in women greater than 35 years of age. A recent clinical study that was not sufficiently powered to achieve statistical meaning, involving Coenzyme Q10 in the IVF setting revealed a higher clinical pregnancy rate in the Coenzyme Q10 group (33%) versus the control group (26.7%). In addition, the rate of aneuploidy (abnormal chromosome copy number in cells) in embryos was higher in the control group (62.8%) relative to the Coenzyme Q10 group (46.5%). Observational studies have shown oxidative stress markers in high concentrations in the follicular fluid and serum of women with infertility; however, there can be no cause and effect relationship confirmed from such studies. Studies of antioxidants in female infertility have been evaluated in a Cochrane review published in 2020. The cochrane review noted that evidence supports that taking an antioxidant may benefit subfertile women. It must be further noted that treatment with nutritional supplements with or without standard infertility treatments (ovulation induction, IVF) has not been subject to statistically robust prospective, randomized clinical trials. References:

Greenberg JA, Bell SJ, Guan Y, Yu YH: Folic acid supplementation and pregnancy: more than just neural tube defect prevention. Rev Obstet Gynecol 2011 4(2) 52-59.
Ben-Meir A, Burstein E, Borrego-Alvarez A, Chong J, et al: Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell 2015 14: 887- 895. doi: 10.1111/acel.12368.
Bentov Y, Hannam T, Jurisicova A, Esfandiari, Casper RF: Coenzyme Q10 supplementation and oocyte aneuploidy in women undergoing IVF-ICSI treatment. Clin Med Insights Reprod Health. 2014 Jun 8;8:31-6. doi: 10.4137/CMRH.S14681. eCollection 2014.
Bentov Y, Casper RF: The aging oocyte- can mitochondrial function be improved? Fertil Steril 2013 Jan;99(1): 18-22. doi: 10.1016/j.fertnstert.2012.11.031.
Ruder EH, Hartman T J, Blumberg J, Mayer J, Goldman MB: Oxidative stress and antioxidants: exposure and impact on female fertility. Hum Reprod Update 2008 14 (4): 345-357.
Luddi A, Capaldo A, Focarelli R, Gori M, et al: Antioxidants reduce oxidative stress in follicular fluid of aged women undergoing IVF. Reprod Bioi Endocrinol 2016 14:57
Showell MG, Brown J, Clarke J, Hart RJ: Antioxidants for female subfertility. Cochrane Database Syst Rev; (8): CD 0078707, 2013 Aug 05.
Gupta S, du Plessis SS, AIQasem S, Nouh M, Cakar Z: Therapeutic Role of antioxidants (AOX) in the treatment of infertility. Oxidative Stress in Human Reproduction 2017 06 May 129-150.
Ruder EH, Hartman T J, Reindollar RH, Goldman MB: Female dietary antioxidant intake and time to pregnancy among couples treated for unexplained infertility. Fertil Steril 2014 101 :3 759-766
Oyawoye OA, Abdei-Gadir A, Garner A, Leonard AJ, et al: The interaction between follicular fluid total antioxidant capacity, infertility and early reproductive outcomes during in vitro fertilization. Redox Rep 2009 14 (5) 205-213
Bentov Y, Hannam T, Jurisicova, Esfandiari N, Casper R: Coenzyme Q 10 supplementation and oocyte aneuploidy in women undergoing IVF-ICSI treatment. Clin Med Insights Reprod Health 2014; 8:31-36.
Antioxidants for female subfertility. Cochrane Database version published 27 August 2020 https://doi.org/10.1002/14651858.CD007807.pub4 Showell MG, Mackenzie-Proctor R, Jordan V, Hart R.J.

Disclaimer: None of the above statements have been evaluated by the United States Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure or prevent any disease. Please consult your health care professional before taking any and all supplements, Individual results may vary. Every Prolog Health product exceeds the standards and requirements set forth in the FDA's Code of Federal Regulation (21 CFR, 111) Current Good Manufacturing Practices (CGMP). All products are made in USA with all ingredients of highest verifiable quality.

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